A-1155463 Hydrochloride

货 号:RLD00000001
店铺价:$110.00 美元
品 牌:TRC
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国 家: 加拿大
库 存:100
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Cat.No:A100800
Chemical Name:A-1155463 Hydrochloride
CAS Number:
Mol.Formula:C35H32FN5O4S2•HCl
Mol.Weight:669.793646
Appearance:Beige Solid
Application Notes:A-1155463 Hydrochloride, is a potent and selective BCL-XL inhibitor with in vivo activity. A-1155463 is a proteolytically stable, cell-permeable and high affinity BH3 mimetic Ligand of BCL protein BCL-XL, binding to the target potently and selectively with a Ki value of<0.01nM (<10 highly="" selective="" against="" closely="" related="" proteins="" of="" bcl-2="" ki="74nM,">7000-fold selectivity), BCL-W (Ki = 8 nM, >800-fold selectivity), and MCL-1 (Ki >444nM, >40000-fold selectivity). A-1155463, together with A-1331852 , represent the first-in-class small molecule BCL-XL selective inhibitors achieving clear-on-target in vivo activity with high potency and selectivity. In living cells, A-1155463, as anticipated, experts an effort to disrupt the tight-binding BCL-XL-BIM, but not BCL-2–BIM, complexes, killing BCL-XL–dependent Molt-4 cells (EC50=70nM) without measurable cytotoxicity against BCL-2–dependent RS4 (ref. 1), inducing the hallmarks of intrinsic apoptosis (ref. 1).
Melting Pt.:>140°C (dec.)
Boiling Pt.:No Data Available
Solubility:No Data Available
Storage Condition:-20°C Freezer, Under inert atmosphere
Shiping Info:
信息来源:https://www.trc-canada.com/product-detail/?CatNum=A100800

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